Publications

@article{vanEimeren2017,

title = {Is Tau Imaging More Than Just Upside-Down ^{18}F-FDG Imaging?},

author = {Thilo van Eimeren and Gérard N. Bischof and Alexander Drzezga},

doi = {10.2967/jnumed.117.190082},

issn = {2159-662X},

year  = {2017},

date = {2017-09-00},

journal = {J Nucl Med},

volume = {58},

number = {9},

pages = {1357--1359},

publisher = {Society of Nuclear Medicine},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28467917,

title = {Resting-state functional reorganization in Parkinson's disease: An activation likelihood estimation meta-analysis},

author = {Masoud Tahmasian and Simon B Eickhoff and Kathrin Giehl and Frank Schwartz and Damian M Herz and Alexander Drzezga and Thilo van Eimeren and Angela R Laird and Peter T Fox and Habibolah Khazaie and Mojtaba Zarei and Carsten Eggers and Claudia R Eickhoff},

doi = {10.1016/j.cortex.2017.03.016},

issn = {1973-8102},

year  = {2017},

date = {2017-07-01},

journal = {Cortex},

volume = {92},

pages = {119--138},

abstract = {Parkinson's disease (PD) is a common progressive neurodegenerative disorder. Studies using resting-state functional magnetic resonance imaging (fMRI) to investigate underlying pathophysiology of motor and non-motor symptoms in PD yielded largely inconsistent results. This quantitative neuroimaging meta-analysis aims to identify consistent abnormal intrinsic functional patterns in PD across studies. We used PubMed to retrieve suitable resting-state studies and stereotactic data were extracted from 28 individual between-group comparisons. Convergence across their findings was tested using the activation likelihood estimation (ALE) approach. We found convergent evidence for intrinsic functional disturbances in bilateral inferior parietal lobule (IPL) and the supramarginal gyrus in PD patients compared to healthy subjects. In follow-up task-based and task-independent functional connectivity (FC) analyses using two independent healthy subject data sets, we found that the regions showing convergent aberrations in PD formed an interconnected network mainly with the default mode network (DMN). Behavioral characterization of these regions using the BrainMap database suggested associated dysfunction of perception and executive processes. Taken together, our findings highlight the role of parietal cortex in the pathophysiology of PD.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Respondek2017,

title = {Which ante mortem clinical features predict progressive supranuclear palsy pathology?},

author = {Gesine Respondek and Carolin Kurz and Thomas Arzberger and Yaroslau Compta and Elisabet Englund and Leslie W. Ferguson and Ellen Gelpi and Armin Giese and David J. Irwin and Wassilios G. Meissner and Christer Nilsson and Alexander Pantelyat and Alex Rajput and John C. van Swieten and Claire Troakes and Keith A. Josephs and Anthony E. Lang and Brit Mollenhauer and Ulrich Müller and Jennifer L. Whitwell and Angelo Antonini and Kailash P. Bhatia and Yvette Bordelon and Jean‐Christophe Corvol and Carlo Colosimo and Richard Dodel and Murray Grossman and Jan Kassubek and Florian Krismer and Johannes Levin and Stefan Lorenzl and Huw Morris and Peter Nestor and Wolfgang H. Oertel and Gil D. Rabinovici and James B. Rowe and Thilo van Eimeren and Gregor K. Wenning and Adam Boxer and Lawrence I. Golbe and Irene Litvan and Maria Stamelou and Günter U. Höglinger and },

doi = {10.1002/mds.27034},

issn = {1531-8257},

year  = {2017},

date = {2017-07-00},

journal = {Movement Disorders},

volume = {32},

number = {7},

pages = {995--1005},

publisher = {Wiley},

abstract = {ABSTRACTBackgroundProgressive supranuclear palsy (PSP) is a neuropathologically defined disease presenting with a broad spectrum of clinical phenotypes.ObjectiveTo identify clinical features and investigations that predict or exclude PSP pathology during life, aiming at an optimization of the clinical diagnostic criteria for PSP.MethodsWe performed a systematic review of the literature published since 1996 to identify clinical features and investigations that may predict or exclude PSP pathology. We then extracted standardized data from clinical charts of patients with pathologically diagnosed PSP and relevant disease controls and calculated the sensitivity, specificity, and positive predictive value of key clinical features for PSP in this cohort.ResultsOf 4166 articles identified by the database inquiry, 269 met predefined standards. The literature review identified clinical features predictive of PSP, including features of the following 4 functional domains: ocular motor dysfunction, postural instability, akinesia, and cognitive dysfunction. No biomarker or genetic feature was found reliably validated to predict definite PSP. High‐quality original natural history data were available from 206 patients with pathologically diagnosed PSP and from 231 pathologically diagnosed disease controls (54 corticobasal degeneration, 51 multiple system atrophy with predominant parkinsonism, 53 Parkinson's disease, 73 behavioral variant frontotemporal dementia). We identified clinical features that predicted PSP pathology, including phenotypes other than Richardson's syndrome, with varying sensitivity and specificity.ConclusionsOur results highlight the clinical variability of PSP and the high prevalence of phenotypes other than Richardson's syndrome. The features of variant phenotypes with high specificity and sensitivity should serve to optimize clinical diagnosis of PSP. © 2017 International Parkinson and Movement Disorder Society},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Whitwell2017,

title = {Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be?},

author = {Jennifer L. Whitwell and Günter U. Höglinger and Angelo Antonini and Yvette Bordelon and Adam L. Boxer and Carlo Colosimo and Thilo van Eimeren and Lawrence I. Golbe and Jan Kassubek and Carolin Kurz and Irene Litvan and Alexander Pantelyat and Gil Rabinovici and Gesine Respondek and Axel Rominger and James B. Rowe and Maria Stamelou and Keith A. Josephs and },

doi = {10.1002/mds.27038},

issn = {1531-8257},

year  = {2017},

date = {2017-07-00},

journal = {Movement Disorders},

volume = {32},

number = {7},

pages = {955--971},

publisher = {Wiley},

abstract = {ABSTRACTPSP is a pathologically defined neurodegenerative tauopathy with a variety of clinical presentations including typical Richardson's syndrome and other variant PSP syndromes. A large body of neuroimaging research has been conducted over the past two decades, with many studies proposing different structural MRI and molecular PET/SPECT biomarkers for PSP. These include measures of brainstem, cortical and striatal atrophy, diffusion weighted and diffusion tensor imaging abnormalities, [18F] fluorodeoxyglucose PET hypometabolism, reductions in striatal dopamine imaging and, most recently, PET imaging with ligands that bind to tau. Our aim was to critically evaluate the degree to which structural and molecular neuroimaging metrics fulfill criteria for diagnostic biomarkers of PSP. We queried the PubMed, Cochrane, Medline, and PSYCInfo databases for original research articles published in English over the past 20 years using postmortem diagnosis or the NINDS‐SPSP criteria as the diagnostic standard from 1996 to 2016. We define a five‐level theoretical construct for the utility of neuroimaging biomarkers in PSP, with level 1 representing group‐level findings, level 2 representing biomarkers with demonstrable individual‐level diagnostic utility, level 3 representing biomarkers for early disease, level 4 representing surrogate biomarkers of PSP pathology, and level 5 representing definitive PSP biomarkers of PSP pathology. We discuss the degree to which each of the currently available biomarkers fit into this theoretical construct, consider the role of biomarkers in the diagnosis of Richardson's syndrome, variant PSP syndromes and autopsy confirmed PSP, and emphasize current shortfalls in the field. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tahmasian2017,

title = {Resting-state functional reorganization in Parkinson's disease: An activation likelihood estimation meta-analysis},

author = {Masoud Tahmasian and Simon B. Eickhoff and Kathrin Giehl and Frank Schwartz and Damian M. Herz and Alexander Drzezga and Thilo van Eimeren and Angela R. Laird and Peter T. Fox and Habibolah Khazaie and Mojtaba Zarei and Carsten Eggers and Claudia R. Eickhoff},

doi = {10.1016/j.cortex.2017.03.016},

issn = {0010-9452},

year  = {2017},

date = {2017-07-00},

journal = {Cortex},

volume = {92},

pages = {119--138},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Höglinger2017,

title = {Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria},

author = {Günter U. Höglinger and Gesine Respondek and Maria Stamelou and Carolin Kurz and Keith A. Josephs and Anthony E. Lang and Brit Mollenhauer and Ulrich Müller and Christer Nilsson and Jennifer L. Whitwell and Thomas Arzberger and Elisabet Englund and Ellen Gelpi and Armin Giese and David J. Irwin and Wassilios G. Meissner and Alexander Pantelyat and Alex Rajput and John C. van Swieten and Claire Troakes and Angelo Antonini and Kailash P. Bhatia and Yvette Bordelon and Yaroslau Compta and Jean-Christophe Corvol and Carlo Colosimo and Dennis W. Dickson and Richard Dodel and Leslie Ferguson and Murray Grossman and Jan Kassubek and Florian Krismer and Johannes Levin and Stefan Lorenzl and Huw R. Morris and Peter Nestor and Wolfgang H. Oertel and Werner Poewe and Gil Rabinovici and James B. Rowe and Gerard D. Schellenberg and Klaus Seppi and Thilo van Eimeren and Gregor K. Wenning and Adam L. Boxer and Lawrence I. Golbe and Irene Litvan and },

doi = {10.1002/mds.26987},

issn = {0885-3185},

year  = {2017},

date = {2017-06-00},

journal = {Mov Disord.},

volume = {32},

number = {6},

pages = {853--864},

publisher = {Wiley},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Strafella2017,

title = {Molecular imaging to track Parkinson's disease and atypical parkinsonisms: New imaging frontiers},

author = {Antonio P. Strafella and Nicolaas I. Bohnen and Joel S. Perlmutter and David Eidelberg and Nicola Pavese and Thilo Van Eimeren and Paola Piccini and Marios Politis and Stephane Thobois and Roberto Ceravolo and Makoto Higuchi and Valtteri Kaasinen and Mario Masellis and M. Cecilia Peralta and Ignacio Obeso and Jose Ángel Pineda-Pardo and Roberto Cilia and Benedicte Ballanger and Martin Niethammer and Jon A. Stoessl and },

doi = {10.1002/mds.26907},

issn = {0885-3185},

year  = {2017},

date = {2017-02-00},

journal = {Mov Disord.},

volume = {32},

number = {2},

pages = {181--192},

publisher = {Wiley},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Trampenau2016,

title = {Processing of probabilistic information in weight perception and motor prediction},

author = {Leif Trampenau and Thilo van Eimeren and Johann Kuhtz-Buschbeck},

doi = {10.3758/s13414-016-1266-5},

issn = {1943-393X},

year  = {2017},

date = {2017-02-00},

journal = {Atten Percept Psychophys},

volume = {79},

number = {2},

pages = {404--414},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid27802224,

title = {In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease},

author = {Julian Dronse and Klaus Fliessbach and Gérard N Bischof and Boris von Reutern and Jennifer Faber and Jochen Hammes and Georg Kuhnert and Bernd Neumaier and Oezguer A Onur and Juraj Kukolja and Thilo van Eimeren and Frank Jessen and Gereon R Fink and Thomas Klockgether and Alexander Drzezga},

doi = {10.3233/JAD-160316},

issn = {1875-8908},

year  = {2017},

date = {2017-01-01},

journal = {J Alzheimers Dis},

volume = {55},

number = {2},

pages = {465--471},

abstract = {The clinical heterogeneity of Alzheimer's disease is not reflected in the rather diffuse cortical deposition of amyloid-β. We assessed the relationship between clinical symptoms, in vivo tau pathology, amyloid distribution, and hypometabolism in variants of Alzheimer's disease using novel multimodal PET imaging techniques. Tau pathology was primarily observed in brain regions related to clinical symptoms and overlapped with areas of hypometabolism. In contrast, amyloid-β deposition was diffusely distributed over the entire cortex. Tau PET imaging may thus serve as a valuable biomarker for the localization of neuronal injury in vivo and may help to validate atypical subtypes of Alzheimer's disease.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hammes2016,

title = {Elevated in vivo [18F]‐AV‐1451 uptake in a patient with progressive supranuclear palsy},

author = {Jochen Hammes and Gérard N. Bischof and Kathrin Giehl and Jennifer Faber and Alexander Drzezga and Thomas Klockgether and Thilo van Eimeren},

doi = {10.1002/mds.26727},

issn = {1531-8257},

year  = {2017},

date = {2017-01-00},

journal = {Movement Disorders},

volume = {32},

number = {1},

pages = {170--171},

publisher = {Wiley},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid28097205,

title = {Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease},

author = {Gérard N Bischof and Frank Jessen and Klaus Fliessbach and Julian Dronse and Jochen Hammes and Bernd Neumaier and Oezguer Onur and Gereon R Fink and Juraj Kukolja and Alexander Drzezga and Thilo van Eimeren and },

doi = {10.1002/acn3.339},

issn = {2328-9503},

year  = {2016},

date = {2016-12-01},

journal = {Ann Clin Transl Neurol},

volume = {3},

number = {12},

pages = {934--939},

abstract = {In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [F]AV-1451) and beta-amyloid burden (measured with [C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [F]FDG-PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta-amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta-amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of A and tau to neurodegeneration in Alzheimer's disease.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bischof2016,

title = {Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease},

author = {Gérard N. Bischof and Frank Jessen and Klaus Fliessbach and Julian Dronse and Jochen Hammes and Bernd Neumaier and Oezguer Onur and Gereon R. Fink and Juraj Kukolja and Alexander Drzezga and Thilo van Eimeren and },

doi = {10.1002/acn3.339},

issn = {2328-9503},

year  = {2016},

date = {2016-12-00},

journal = {Ann Clin Transl Neurol},

volume = {3},

number = {12},

pages = {934--939},

publisher = {Wiley},

abstract = {AbstractIn a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [18F]AV‐1451) and beta‐amyloid burden (measured with [11C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [18F]FDG‐PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta‐amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta‐amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of Aβ and tau to neurodegeneration in Alzheimer's disease.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Dronse2016,

title = {In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer’s Disease},

author = {Julian Dronse and Klaus Fliessbach and Gérard N. Bischof and Boris von Reutern and Jennifer Faber and Jochen Hammes and Georg Kuhnert and Bernd Neumaier and Oezguer A. Onur and Juraj Kukolja and Thilo van Eimeren and Frank Jessen and Gereon R. Fink and Thomas Klockgether and Alexander Drzezga},

doi = {10.3233/jad-160316},

issn = {1875-8908},

year  = {2016},

date = {2016-11-19},

journal = {JAD},

volume = {55},

number = {2},

pages = {465--471},

publisher = {SAGE Publications},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rempe2016,

title = {Early-onset parkinsonism due to compound heterozygous POLG mutations},

author = {Torge Rempe and Gregor Kuhlenbäumer and Stefanie Krüger and Saskia Biskup and Jakob Matschke and Christian Hagel and Günther Deuschl and Thilo van Eimeren},

doi = {10.1016/j.parkreldis.2016.04.020},

issn = {1353-8020},

year  = {2016},

date = {2016-08-00},

journal = {Parkinsonism & Related Disorders},

volume = {29},

pages = {135--137},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Lorenzen2016,

title = {Chemosensory processing in children with attention-deficit/hyperactivity disorder},

author = {Anna Lorenzen and Deborah Scholz-Hehn and Christian D. Wiesner and Stephan Wolff and Til O. Bergmann and Thilo van Eimeren and Luisa Lentfer and Lioba Baving and Alexander Prehn-Kristensen},

doi = {10.1016/j.jpsychires.2016.02.007},

issn = {0022-3956},

year  = {2016},

date = {2016-05-00},

journal = {Journal of Psychiatric Research},

volume = {76},

pages = {121--127},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ponseti2015,

title = {Assessing paedophilia based on the haemodynamic brain response to face images},

author = {Jorge Ponseti and Oliver Granert and Thilo Van Eimeren and Olav Jansen and Stephan Wolff and Klaus Beier and Günther Deuschl and Christian Huchzermeier and Aglaja Stirn and Hartmut Bosinski and Hartwig Roman Siebner},

doi = {10.3109/15622975.2015.1083612},

issn = {1814-1412},

year  = {2016},

date = {2016-01-02},

journal = {The World Journal of Biological Psychiatry},

volume = {17},

number = {1},

pages = {39--46},

publisher = {Informa UK Limited},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Zeuner2016,

title = {Altered brain activation in a reversal learning task unmasks adaptive changes in cognitive control in writer's cramp},

author = {Kirsten E. Zeuner and Arne Knutzen and Oliver Granert and Simone Sablowsky and Julia Götz and Stephan Wolff and Olav Jansen and Dirk Dressler and Susanne A. Schneider and Christine Klein and Günther Deuschl and Thilo van Eimeren and Karsten Witt},

doi = {10.1016/j.nicl.2015.11.006},

issn = {2213-1582},

year  = {2016},

date = {2016-00-00},

journal = {NeuroImage: Clinical},

volume = {10},

pages = {63--70},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tahmasian2015b,

title = {A systematic review on the applications of resting-state fMRI in Parkinson's disease: Does dopamine replacement therapy play a role?},

author = {Masoud Tahmasian and Lisa M. Bettray and Thilo van Eimeren and Alexander Drzezga and Lars Timmermann and Claudia R. Eickhoff and Simon B. Eickhoff and Carsten Eggers},

doi = {10.1016/j.cortex.2015.08.005},

issn = {0010-9452},

year  = {2015},

date = {2015-12-00},

journal = {Cortex},

volume = {73},

pages = {80--105},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Granert2015,

title = {Metabolic Topology of Neurodegenerative Disorders: Influence of Cognitive and Motor Deficits},

author = {Oliver Granert and Alexander E. Drzezga and Henning Boecker and Robert Perneczky and Alexander Kurz and Julia Götz and Thilo van Eimeren and Peter Häussermann},

doi = {10.2967/jnumed.115.156067},

issn = {2159-662X},

year  = {2015},

date = {2015-12-00},

journal = {J Nucl Med},

volume = {56},

number = {12},

pages = {1916--1921},

publisher = {Society of Nuclear Medicine},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tahmasian2015,

title = {Impulsivity is Associated with Increased Metabolism in the Fronto-Insular Network in Parkinson’s Disease},

author = {Masoud Tahmasian and Luisa Rochhausen and Franziska Maier and Kim L. Williamson and Alexander Drzezga and Lars Timmermann and Thilo Van Eimeren and Carsten Eggers},

doi = {10.3389/fnbeh.2015.00317},

issn = {1662-5153},

year  = {2015},

date = {2015-11-30},

journal = {Front. Behav. Neurosci.},

volume = {9},

publisher = {Frontiers Media SA},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Probst2015,

title = {Erratum to: Validation of the questionnaire for impulsive-compulsive disorders in Parkinson’s disease (QUIP) and the QUIP-rating scale in a German speaking sample},

author = {Catharina Claudia Probst and Lina Marie Winter and Bettina Möller and Heinz Weber and Daniel Weintraub and Karsten Witt and Günther Deuschl and Regina Katzenschlager and Thilo van Eimeren},

doi = {10.1007/s00415-015-7882-5},

issn = {1432-1459},

year  = {2015},

date = {2015-09-00},

journal = {J Neurol},

volume = {262},

number = {9},

pages = {2200--2200},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Gerwinn2015,

title = {The (in)consistency of changes in brain macrostructure in male paedophiles: A combined T1-weighted and diffusion tensor imaging study},

author = {Hannah Gerwinn and Alexander Pohl and Oliver Granert and Thilo van Eimeren and Stephan Wolff and Olav Jansen and Günther Deuschl and Christian Huchzermeier and Aglaja Stirn and Hartwig Roman Siebner and Jorge Ponseti},

doi = {10.1016/j.jpsychires.2015.07.002},

issn = {0022-3956},

year  = {2015},

date = {2015-09-00},

journal = {Journal of Psychiatric Research},

volume = {68},

pages = {246--253},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Trampenau2015,

title = {Probabilistic information on object weight shapes force dynamics in a grip-lift task},

author = {Leif Trampenau and Johann P. Kuhtz-Buschbeck and Thilo van Eimeren},

doi = {10.1007/s00221-015-4244-6},

issn = {1432-1106},

year  = {2015},

date = {2015-06-00},

journal = {Exp Brain Res},

volume = {233},

number = {6},

pages = {1711--1720},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Zeuner2014,

title = {Increased volume and impaired function: the role of the basal ganglia in writer's cramp},

author = {Kirsten E. Zeuner and Arne Knutzen and Oliver Granert and Julia Götz and Stephan Wolff and Olav Jansen and Dirk Dressler and Harald Hefter and Mark Hallett and Günther Deuschl and Thilo van Eimeren and Karsten Witt},

doi = {10.1002/brb3.301},

issn = {2162-3279},

year  = {2015},

date = {2015-02-00},

journal = {Brain and Behavior},

volume = {5},

number = {2},

publisher = {Wiley},

abstract = {AbstractIntroductionThe pathophysiology of writer's cramp, a task‐specific dystonia, remains unclear. The objective of this study was to investigate the basal ganglia circuit and the cerebellum during a complex motor sequence learning task carried out with the nonaffected hand in writer's cramp patients.MethodsWe applied structural and functional imaging in 22 writer's cramp patients and 28 matched controls using 3T MRI. With the asymptomatic left hand all participants learned a complex, sequential, five‐element sequence‐tapping task as accurately and quickly as possible. Functional imaging was measured during a repeated (15 times), fixed block design with tapping (30 sec) and rest (30 sec). Additionally, gray matter volume of the basal ganglia was analyzed using voxel‐based morphometry (VBM).ResultsWhile behavior was comparable between groups, after small volume correction the anterior part of the right putamen and the left globus pallidus exhibited reduced blood oxygen level‐dependent (BOLD) activity in patients during the sequential finger‐tapping task. VBM analysis showed larger gray matter volume bilateral in the posterior part of the putamen and globus pallidus. There were no group differences in the cerebellum.ConclusionThe results indicate an impairment of anterior basal ganglia loops involved in producing complex sequential movements of the unaffected hand. These findings are in line with previous reports of reduced neuronal activity in the globus pallidus internus. Higher gray matter volume of the putamen and globus pallidus may stem from elevated activity of the direct pathway, which could reflect a compensatory phenomenon or a primary predisposition, that is, endophenotypic trait.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Probst2014,

title = {Validation of the questionnaire for impulsive-compulsive disorders in Parkinson’s disease (QUIP) and the QUIP-rating scale in a German speaking sample},

author = {Catharina Claudia Probst and Lina Marie Winter and Bettina Möller and Heinz Weber and Daniel Weintraub and Karsten Witt and Günther Deuschl and Regina Katzenschlager and Thilo van Eimeren},

doi = {10.1007/s00415-014-7299-6},

issn = {1432-1459},

year  = {2014},

date = {2014-05-00},

journal = {J Neurol},

volume = {261},

number = {5},

pages = {936--942},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Goerlich‐Dobre2013,

title = {Alexithymia—an independent risk factor for impulsive‐compulsive disorders in Parkinson's disease},

author = {Katharina S. Goerlich‐Dobre and Catharina Probst and Lina Winter and Karsten Witt and Günther Deuschl and Bettina Möller and Thilo van Eimeren},

doi = {10.1002/mds.25679},

issn = {1531-8257},

year  = {2014},

date = {2014-02-00},

journal = {Movement Disorders},

volume = {29},

number = {2},

pages = {214--220},

publisher = {Wiley},

abstract = {ABSTRACTImpulsive‐compulsive disorders (ICDs) are frequent side effects of dopaminergic medication in Parkinson's disease (PD). Alexithymia, a personality trait characterized by difficulties identifying and describing feelings and an externally oriented thinking style, has been linked to various impulse‐control problems in the general population. In PD, the prevalence of alexithymia is approximately twice as high as in the general population. However, whether alexithymia is associated with ICDs in PD is currently unknown. We examined the relationship between self‐reported ICDs and alexithymia in a sample of 91 PD patients (89 on dopaminergic medication). Additional self‐report measures assessed impulsivity, depression, anxiety, behavioral inhibition/approach, and emotion‐regulation strategies. We observed that alexithymia, and particularly difficulty identifying feelings and difficulty describing feelings, was significantly correlated with ICDs, even when controlling for impulsivity, anxiety, and depression. In addition, a group analysis revealed that PD patients with clinical and moderate levels of alexithymia had significantly more ICDs than non‐alexithymic patients, suggesting that even moderately high alexithymia levels increase the risk for ICDs in PD. Our results identify alexithymia as an independent risk factor for ICDs in PD. Thus, the inclusion of alexithymia in the neuropsychiatric assessment of patients with PD may help identify patients at risk for ICDs. © 2013 International Parkinson and Movement Disorder Society},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Probst2013,

title = {The Functional Anatomy of Impulse Control Disorders},

author = {Catharina C. Probst and Thilo van Eimeren},

doi = {10.1007/s11910-013-0386-8},

issn = {1534-6293},

year  = {2013},

date = {2013-10-00},

journal = {Curr Neurol Neurosci Rep},

volume = {13},

number = {10},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Witt2013,

title = {Relation of lead trajectory and electrode position to neuropsychological outcomes of subthalamic neurostimulation in Parkinson’s disease: results from a randomized trial},

author = {Karsten Witt and Oliver Granert and Christine Daniels and Jens Volkmann and Daniela Falk and Thilo van Eimeren and Günther Deuschl},

doi = {10.1093/brain/awt151},

issn = {1460-2156},

year  = {2013},

date = {2013-07-00},

volume = {136},

number = {7},

pages = {2109--2119},

publisher = {Oxford University Press (OUP)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Burciu2013,

title = {Brain Changes Associated with Postural Training in Patients with Cerebellar Degeneration: A Voxel-Based Morphometry Study},

author = {Roxana Gabriela Burciu and Nicole Fritsche and Oliver Granert and Lutz Schmitz and Nina Spönemann and Jürgen Konczak and Nina Theysohn and Marcus Gerwig and Thilo van Eimeren and Dagmar Timmann},

doi = {10.1523/jneurosci.3381-12.2013},

issn = {1529-2401},

year  = {2013},

date = {2013-03-06},

journal = {J. Neurosci.},

volume = {33},

number = {10},

pages = {4594--4604},

publisher = {Society for Neuroscience},

abstract = {Recent research indicates that physiotherapy can improve motor performance of patients with cerebellar degeneration. Given the known contributions of the cerebellum to motor learning, it remains unclear whether such observable changes in performance are mediated by the cerebellum or cerebral brain areas involved in motor control and learning. The current study addressed this question by assessing the increase in gray matter volume due to sensorimotor training in cerebellar patients using voxel-based morphometry. Nineteen human subjects with pure cerebellar degeneration and matched healthy controls were trained for 2 weeks on a balance task. Postural and clinical assessments along with structural magnetic resonance imaging were performed pretraining and post-training. The main findings were as follows. First, training enhanced balance performance in cerebellar patients. Second, in contrast to controls patients revealed significantly more post-training gray matter volume in the dorsal premotor cortex. Third, training-related increase in gray matter volume was observed within the cerebellum and was more pronounced in controls than in patients. However, statistically cerebellar changes were at the trend level and thus require additional, independent confirmation. We conclude that sensorimotor training of patients with cerebellar neurodegeneration induces gray matter changes primarily within nonaffected neocortical regions of the cerebellar-cortical loop. Residual function of the cerebellum appears to be exploited suggesting either a recovery from degeneration or intact processes of cerebellar plasticity in the remaining healthy tissue.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{vanEimeren2011,

title = {Prefrontal D2‐receptor stimulation mediates flexible adaptation of economic preference hierarchies},

author = {Thilo van Eimeren and Ji H. Ko and Giovanna Pellechia and Sang S. Cho and Sylvain Houle and Antonio P. Strafella},

doi = {10.1002/hbm.21425},

issn = {1097-0193},

year  = {2013},

date = {2013-01-00},

journal = {Human Brain Mapping},

volume = {34},

number = {1},

pages = {226--232},

publisher = {Wiley},

abstract = {AbstractAdvantageous economic decision making requires flexible adaptation of gain‐based and loss‐based preference hierarchies. However, where the neuronal blueprints for economic preference hierarchies are kept and how they may be adapted remains largely unclear. Phasic cortical dopamine release likely mediates flexible adaptation of neuronal representations. In this PET study, cortical‐binding potential (BP) for the D2‐dopamine receptor ligand [11C]FLB 457 was examined in healthy participants during multiple sessions of a probabilistic four‐choice financial decision‐making task with two behavioral variants. In the changing‐gains/constant‐losses variant, the implicit gain‐based preference hierarchy was unceasingly changing, whereas the implicit loss‐based preference hierarchy was constant. In the constant‐gains/changing‐losses variant, it was the other way around. These variants served as paradigms, respectively, contrasting flexible adaptation versus maintenance of loss‐based and gain‐based preference hierarchies. We observed that in comparison with the constant‐gains/changing‐losses variant, the changing‐gains/constant‐losses variant was associated with a decreased D2‐dopamine receptor‐BP in the right lateral frontopolar cortex. In other words, lateral frontopolar D2‐dopamine receptor stimulation was specifically increased during continuous adaptation of mental representations of gain‐based preference hierarchies. This finding provides direct evidence for the existence of a neuronal blueprint of gain‐based decision‐making in the lateral frontopolar cortex and a crucial role of local dopamine in the flexible adaptation of mental concepts of future behavior. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Smith2011,

title = {Serotonin Transporter Occupancy and the Functional Neuroanatomic Effects of Citalopram in Geriatric Depression},

author = {Gwenn S. Smith and Alan Kahn and Julia Sacher and Pablo Rusjan and Thilo van Eimeren and Alastair Flint and Alan A. Wilson},

doi = {10.1097/jgp.0b013e318227f83f},

issn = {1064-7481},

year  = {2011},

date = {2011-12-00},

journal = {The American Journal of Geriatric Psychiatry},

volume = {19},

number = {12},

pages = {1016--1025},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Cilia2011,

title = {Impulse control disorders in Parkinson’s disease: seeking a roadmap toward a better understanding},

author = {Roberto Cilia and Thilo van Eimeren},

doi = {10.1007/s00429-011-0314-0},

issn = {1863-2661},

year  = {2011},

date = {2011-11-00},

journal = {Brain Struct Funct},

volume = {216},

number = {4},

pages = {289--299},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Cilia2011b,

title = {Pathological gambling in patients with Parkinson's disease is associated with fronto-striatal disconnection: A path modeling analysis},

author = {Roberto Cilia and Sang Soo Cho and Thilo van Eimeren and Giorgio Marotta and Chiara Siri and Ji Hyun Ko and Giovanna Pellecchia and Gianni Pezzoli and Angelo Antonini and Antonio P. Strafella},

doi = {10.1002/mds.23480},

issn = {0885-3185},

year  = {2011},

date = {2011-02-01},

journal = {Mov. Disord.},

volume = {26},

number = {2},

pages = {225--233},

publisher = {Wiley},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Cho2010,

title = {Continuous theta burst stimulation of right dorsolateral prefrontal cortex induces changes in impulsivity level},

author = {Sang Soo Cho and Ji Hyun Ko and Giovanna Pellecchia and Thilo Van Eimeren and Roberto Cilia and Antonio P. Strafella},

doi = {10.1016/j.brs.2009.10.002},

issn = {1935-861X},

year  = {2010},

date = {2010-07-00},

journal = {Brain Stimulation},

volume = {3},

number = {3},

pages = {170--176},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{vanEimeren2010,

title = {Imaging movement-related activity in medicated Parkin-associated and sporadic Parkinson’s disease},

author = {Thilo van Eimeren and Ferdinand Binkofski and Carsten Buhmann and Johann Hagenah and Antonio P. Strafella and Peter P. Pramstaller and Hartwig R. Siebner and Christine Klein},

doi = {10.1016/j.parkreldis.2010.04.003},

issn = {1353-8020},

year  = {2010},

date = {2010-07-00},

journal = {Parkinsonism & Related Disorders},

volume = {16},

number = {6},

pages = {384--387},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Cilia2010,

title = {Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling},

author = {Roberto Cilia and Ji Hyun Ko and Sang Soo Cho and Thilo van Eimeren and Giorgio Marotta and Giovanna Pellecchia and Gianni Pezzoli and Angelo Antonini and Antonio P. Strafella},

doi = {10.1016/j.nbd.2010.03.013},

issn = {0969-9961},

year  = {2010},

date = {2010-07-00},

journal = {Neurobiology of Disease},

volume = {39},

number = {1},

pages = {98--104},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ballanger2010,

title = {Serotonin 2A Receptors and Visual Hallucinations in Parkinson Disease},

author = {Benedicte Ballanger and Antonio P. Strafella and Thilo van Eimeren and Mateusz Zurowski and Pablo M. Rusjan and Sylvain Houle and Susan H. Fox},

doi = {10.1001/archneurol.2010.35},

issn = {0003-9942},

year  = {2010},

date = {2010-04-12},

journal = {Arch Neurol},

volume = {67},

number = {4},

publisher = {American Medical Association (AMA)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ballanger2009,

title = {Stimulation of the subthalamic nucleus and impulsivity: Release your horses},

author = {Benedicte Ballanger and Thilo van Eimeren and Elena Moro and Andres M. Lozano and Clement Hamani and Philippe Boulinguez and Giovanna Pellecchia and Sylvain Houle and Yu Yan Poon and Anthony E. Lang and Antonio P. Strafella},

doi = {10.1002/ana.21795},

issn = {1531-8249},

year  = {2009},

date = {2009-12-00},

journal = {Annals of Neurology},

volume = {66},

number = {6},

pages = {817--824},

publisher = {Wiley},

abstract = {AbstractObjectiveIn Parkinson disease (PD) patients, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may contribute to certain impulsive behavior during high‐conflict decisions. A neurocomputational model of the basal ganglia has recently been proposed that suggests this behavioral aspect may be related to the role played by the STN in relaying a “hold your horses” signal intended to allow more time to settle on the best option. The aim of the present study was 2‐fold: 1) to extend these observations by providing evidence that the STN may influence and prevent the execution of any response even during low‐conflict decisions; and 2) to identify the neural correlates of this effect.MethodsWe measured regional cerebral blood flow during a Go/NoGo and a control (Go) task to study the motor improvement and response inhibition deficits associated with STN‐DBS in patients with PD.ResultsAlthough it improved Unified Parkinson Disease Rating Scale motor ratings and induced a global decrease in reaction time during task performance, STN‐DBS impaired response inhibition, as revealed by an increase in commission errors in NoGo trials. These behavioral effects were accompanied by changes in synaptic activity consisting of a reduced activation in the cortical networks responsible for reactive and proactive response inhibition.InterpretationThe present results suggest that although it improves motor functions in PD patients, modulation of STN hyperactivity with DBS may tend at the same time to favor the appearance of impulsive behavior by acting on the gating mechanism involved in response initiation. Ann Neurol 2009;66:817–824},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{vanEimeren2009,

title = {Dopamine Agonists Diminish Value Sensitivity of the Orbitofrontal Cortex: A Trigger for Pathological Gambling in Parkinson's Disease?},

author = {Thilo van Eimeren and Bénédicte Ballanger and Giovanna Pellecchia and Janis M Miyasaki and Anthony E Lang and Antonio P Strafella},

doi = {10.1038/npp.2009.124},

issn = {1740-634X},

year  = {2009},

date = {2009-12-00},

journal = {Neuropsychopharmacol},

volume = {34},

number = {13},

pages = {2758--2766},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ballanger2009b,

title = {Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: A [^{15}O] H_{2}O PET study},

author = {Benedicte Ballanger and Andres M. Lozano and Elena Moro and Thilo van Eimeren and Clement Hamani and Robert Chen and Roberto Cilia and Sylvain Houle and Yu Yan Poon and Anthony E. Lang and Antonio P. Strafella},

doi = {10.1002/hbm.20815},

issn = {1097-0193},

year  = {2009},

date = {2009-12-00},

journal = {Human Brain Mapping},

volume = {30},

number = {12},

pages = {3901--3909},

publisher = {Wiley},

abstract = {AbstractPatients with advanced Parkinson's disease (PD) develop disabling axial symptoms, including gait disturbances, freezing and postural instability poorly responsive to levodopa replacement therapy. The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement sleep]. Recent reports suggested that PPN modulation with deep brain stimulation (DBS) may be beneficial in the treatment of axial symptoms. However, the mechanisms underlying these effects are still unknown. We used [15O] H2O PET to investigate regional cerebral blood flow in three patients with advanced PD who underwent a new experimental surgical procedure with implantation of unilateral PPN‐DBS. Patients were studied Off‐medication with stimulator Off and On, both at rest and during a self‐paced alternating motor task of the lower limbs. We used SPM2 for imaging data analysis, threshold P < 0.05 corrected at the cluster level. Stimulation induced significant regional cerebral blood flow increment in subcortical regions such as the thalamus (P < 0.006), cerebellum (P < 0.001), and midbrain region (P < 0.001) as well as different cortical areas involving medial sensorimotor cortex extending into caudal supplementary motor area (BA 4/6; P < 0.001). PPN‐DBS in advanced PD resulted in blood flow and presumably neuronal activity changes in subcortical and cortical areas involved in balance and motor control, including the mesencephalic locomotor region (e.g. PPN) and closely interconnected structures within the cerebello‐(rubro)‐thalamo‐cortical circuit. Whether these findings are associated with the DBS‐PPN clinical effect remains to be proven. However, they suggest that PPN modulation may induce functional changes in neural networks associated with the control of lower limb movements. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{vanEimeren2009b,

title = {Dysfunction of the Default Mode Network in Parkinson Disease},

author = {Thilo van Eimeren and Oury Monchi and Benedicte Ballanger and Antonio P. Strafella},

doi = {10.1001/archneurol.2009.97},

issn = {0003-9942},

year  = {2009},

date = {2009-07-01},

journal = {Arch Neurol},

volume = {66},

number = {7},

publisher = {American Medical Association (AMA)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ko2009,

title = {Increased dopamine release in the right anterior cingulate cortex during the performance of a sorting task: A [11C]FLB 457 PET study},

author = {Ji Hyun Ko and Alain Ptito and Oury Monchi and Sang Soo Cho and Thilo Van Eimeren and Giovanna Pellecchia and Benedicte Ballanger and Pablo Rusjan and Sylvain Houle and Antonio P. Strafella},

doi = {10.1016/j.neuroimage.2009.02.031},

issn = {1053-8119},

year  = {2009},

date = {2009-06-00},

journal = {NeuroImage},

volume = {46},

number = {2},

pages = {516--521},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{vanNuenen2009,

title = {Mapping preclinical compensation in Parkinson's disease: An imaging genomics approach},

author = {Bart F.L. van Nuenen and Thilo van Eimeren and Joyce P.M. van der Vegt and Carsten Buhmann and Christine Klein and Bastiaan R. Bloem and Hartwig R. Siebner},

doi = {10.1002/mds.22635},

issn = {1531-8257},

year  = {2009},

date = {2009-01-00},

journal = {Movement Disorders},

volume = {24},

number = {S2},

publisher = {Wiley},

abstract = {AbstractMutations in the Parkin (PARK2) and PINK1 gene (PARK 6) can cause recessively inherited Parkinson's disease (PD). The presence of a single Parkin or PINK1 mutation is associated with a dopaminergic nigrostriatal dysfunction and conveys an increased risk to develop PD throughout lifetime. Therefore neuroimaging of non‐manifesting individuals with a mutant Parkin or PINK1 allele opens up a window for the investigation of preclinical and very early phases of PD in vivo. Here we review how functional magnetic resonance imaging (fMRI) can be used to identify compensatory mechanisms that help to prevent development of overt disease. In two separate experiments, Parkin mutation carriers displayed stronger activation of rostral supplementary motor area (SMA) and right dorsal premotor cortex (PMd) during a simple motor sequence task and anterior cingulate motor area and left rostral PMd during internal movement selection as opposed to externally cued movements. The additional recruitment of the rostral SMA and right rostral PMd during the finger sequence task was also observed in a separate group of nonmanifesting mutation carriers with a single heterozygous PINK1 mutation. Because mutation carriers were not impaired at performing the task, the additional recruitment of motor cortical areas indicates a compensatory mechanism that effectively counteracts the nigrostriatal dysfunction. These first results warrant further studies that use these imaging genomics approach to tap into preclinical compensation of PD. Extensions of this line of research involve fMRI paradigms probing nonmotor brain functions. Additionally, the same fMRI paradigms should be applied to nonmanifesting mutation carriers in genes linked to autosomal dominant PD. This will help to determine how “generically” the human brain compensates for a preclinical dopaminergic dysfunction. © 2009 Movement Disorder Society},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Klöppel2007,

title = {Can Left-Handedness be Switched? Insights from an Early Switch of Handwriting},

author = {Stefan Klöppel and Anna Vongerichten and Thilo van Eimeren and Richard S. J. Frackowiak and Hartwig R. Siebner},

doi = {10.1523/jneurosci.1299-07.2007},

issn = {1529-2401},

year  = {2007},

date = {2007-07-18},

journal = {J. Neurosci.},

volume = {27},

number = {29},

pages = {7847--7853},

publisher = {Society for Neuroscience},

abstract = {“Converted” left-handers are innately left-handed individuals forced as children to write with the right nondominant hand. We asked how a left-to-right handwriting switch shapes cortical sensorimotor representations of finger movements. In 16 adult converted left-handers and age-matched groups of 16 consistent right-handers and 16 left-handers, we studied movement-related neuronal activity with functional magnetic resonance imaging while participants performed simple unimanual and bimanual movements with right and left index fingers. In converted left-handers, movement-related activity in the primary sensorimotor hand area (SM1) and caudal dorsal premotor cortex (PMd) of the nondominant left hemisphere correlated with the left-to-right shift in handedness. The more right-handed converted left-handers had become, the greater the sensorimotor activation in these areas. Between-group comparisons showed that the switch from left to right hand also reinforced movement representations in the dominant right hemisphere. In converted left-handers, the right inferior parietal cortex and lateral PMd were more active relative to consistent right or left-handers in all motor tasks. These results suggest two distinct neuronal correlates of handedness in human sensorimotor cortex. Although those in executive sensorimotor cortex (i.e., SM1 and adjacent PMd) depend on the hand used throughout life, those in higher-order sensorimotor areas (i.e., inferior parietal cortex and rostrolateral PMd) are invariant and thus cannot be switched to the nondominant hemisphere by educational training.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Klöppel2007b,

title = {The effect of handedness on cortical motor activation during simple bilateral movements},

author = {Stefan Klöppel and Thilo van Eimeren and Volkmar Glauche and Anna Vongerichten and Alexander Münchau and Richard S.J. Frackowiak and Christian Büchel and Cornelius Weiller and Hartwig R. Siebner},

doi = {10.1016/j.neuroimage.2006.08.038},

issn = {1053-8119},

year  = {2007},

date = {2007-01-00},

journal = {NeuroImage},

volume = {34},

number = {1},

pages = {274--280},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Eimeren2006,

title = {An update on functional neuroimaging of parkinsonism and dystonia},

author = {Thilo van Eimeren and Hartwig Roman Siebner},

doi = {10.1097/01.wco.0000236623.68625.54},

issn = {1350-7540},

year  = {2006},

date = {2006-08-00},

journal = {Current Opinion in Neurology},

volume = {19},

number = {4},

pages = {412--419},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{vanEimeren2006,

title = {Implementation of visuospatial cues in response selection},

author = {Thilo van Eimeren and Thomas Wolbers and Alexander Münchau and Christian Büchel and Cornelius Weiller and Hartwig Roman Siebner},

doi = {10.1016/j.neuroimage.2005.07.014},

issn = {1053-8119},

year  = {2006},

date = {2006-01-00},

journal = {NeuroImage},

volume = {29},

number = {1},

pages = {286--294},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}