2024
Theis, Hendrik; Barbe, Michael T.; Drzezga, Alexander; Fink, Gereon R.; Neumaier, Bernd; Bischof, Gérard N.; van Eimeren, Thilo
Progressive Supranuclear Palsy: Subcortical Tau Depositions Are Associated with Cortical Perfusion in Frontal and Limbic Regions Journal Article
In: Journal of Parkinson’s Disease, vol. 14, no. 6, pp. 1271–1276, 2024, ISSN: 1877-718X.
Abstract | Links | BibTeX | Tags: Perfusion, PSP, Tau PET
@article{Theis2024,
title = {Progressive Supranuclear Palsy: Subcortical Tau Depositions Are Associated with Cortical Perfusion in Frontal and Limbic Regions},
author = {Hendrik Theis and Michael T. Barbe and Alexander Drzezga and Gereon R. Fink and Bernd Neumaier and Gérard N. Bischof and Thilo van Eimeren},
doi = {10.3233/jpd-240210},
issn = {1877-718X},
year = {2024},
date = {2024-09-03},
urldate = {2024-09-03},
journal = {Journal of Parkinson’s Disease},
volume = {14},
number = {6},
pages = {1271--1276},
publisher = {SAGE Publications},
abstract = { In progressive supranuclear palsy (PSP), subcortical tau and cortical perfusion can be assessed using the tracer ^{18</jsup>F]PI-2620. We investigated if subcortical tau (globus pallidus internus, dentate nucleus) and frontal/limbic perfusion correlate in a cohort of 32 PSP patients. Tau in subcortical regions showed significant negative correlation with perfusion in limbic cortex. Perfusion in frontal regions was negatively associated with tau in both subcortical regions, but the significance threshold was only passed for the dentate nucleus. A reason could be a diaschisis-like phenomenon; that is, subcortical tau could lead to reduced connectivity to frontal regions and, thereby, to decreased perfusion. },
keywords = {Perfusion, PSP, Tau PET},
pubstate = {published},
tppubtype = {article}
}
In progressive supranuclear palsy (PSP), subcortical tau and cortical perfusion can be assessed using the tracer 18</jsup>F]PI-2620. We investigated if subcortical tau (globus pallidus internus, dentate nucleus) and frontal/limbic perfusion correlate in a cohort of 32 PSP patients. Tau in subcortical regions showed significant negative correlation with perfusion in limbic cortex. Perfusion in frontal regions was negatively associated with tau in both subcortical regions, but the significance threshold was only passed for the dentate nucleus. A reason could be a diaschisis-like phenomenon; that is, subcortical tau could lead to reduced connectivity to frontal regions and, thereby, to decreased perfusion.