Hendrik Theis, M.D.

Hendrik Theis is a resident physician at the Department of Neurology at the University Hospital of Cologne and a researcher in the Multimodal Imaging Group. His research focus is the dopaminergic modulation of brain networks. He is investigating changes of fronto-striatal connectivity in Parkinson’s patients with impulse-control disorders and he is also interested in reward learning in obesity.



Hammes, J, Theis, H, Giehl, K, Hoenig, MC, Greuel, A, Tittgemeyer, M et al.. Dopamine metabolism of the nucleus accumbens and fronto-striatal connectivity modulate impulse control. Brain. 2019;142 (3):733-743.

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Hendrik Theis


Merle Hönig, PhD

Merle Hönig’s research interest is focused on the investigation of resilience mechanisms in neurodegenerative diseases. As part of her work, she elucidates the role of lifetime factors such as education, occupation, nutrition and physical activity in regard to the occurrence and extent of neuropathology and changes in network function in Alzheimer’s and Parkinson’s disease. In addition, she is interested in genetic and epigenetic changes and how these factors are, in turn, associated with resilience mechanisms.

Selected publications:

Hönig MC, Bischof GN, Hammes J, Faber J, Fliessbach K, van Eimeren T, et al. Tau pathology and cognitive reserve in Alzheimer’s disease. Neurobiol Aging. 2017 Sep;57:1–7.

Hönig MC, Bischof GN, Seemiller J, Hammes J, Kukolja J, Onur Ö, Jessen F, Fliessbach K, Neumaier B, Fink GR, van Eimeren T, Drzezga A. Networks of tau distribution in Alzheimer’s disease. Brain, 2018

Hönig MC, Bischof GN, Özgür OA, Kukolja J, Jessen F, Fliessbach K, Neumaier B, Fink GR, Kalbe E, Drzezga A, van Eimeren T: Level of education mitigates the impact of tau pathology on neuronal function. Eur J Nucl Med Mol Imaging.2019 Aug;46(9):1787-1795

Curriculum Vitae (Hoenig_CV)

Kathrin Giehl, PhD

Kathrin Giehl’s primary research focus is to advance the understanding of underlying neural mechanisms involved in Parkinson’s disease. She is particularly interested in elucidating mechanism responsible for distinct cognitive impairments, which are frequently observed in this patient cohort, and to investigate the effects of cognitive training on a neural and behavioral level in order to ameliorate these difficulties. For her research, she utilizes behavioral paradigms and various neuroimaging methods, such as functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET). In addition, she organizes and coordinates a broad range of investigator-initiated and industry-sponsored trials with a focus on neuroimaging and neurodegenerative disorders, especially Alzheimer’s and Parkinson’s disease.


Giehl K, Ophey A, Hammes J, Rehberg S, Lichtenstein T, Reker P, Eggers C, Kalbe E & van Eimeren T. Working memory training increases neural efficiency in Parkinson’s disease: a randomized-controlled trial, Brain Communications, 2020.

Ophey A, Giehl K, Rehberg S, Eggers C, Reker P, van Eimeren T & Kalbe E. Effects of working memory training in patients with Parkinson’s disease without cognitive impairment: A randomized controlled trial. Parkinsonism & related disorders. 2020 Feb 11.

Giehl K, Ophey A, Reker P, Rehberg S, Hammes J, Barbe MT, Zokaei N, Eggers C, Husain M, Kalbe E, van Eimeren T. Effects of Home-Based Working Memory Training on Visuo-Spatial Working Memory in Parkinson’s Disease: A Randomized Controlled Trial. Journal of Central Nervous System Disease. 2020 Jan; 12:1179573519899469.

Hammes J, Theis H, Giehl K, Hoenig MC, Greuel A, Tittgemeyer M, Timmermann L, Fink GR, Drzezga A, Eggers C, van Eimeren T. Dopamine metabolism of the nucleus accumbens and fronto-striatal connectivity modulate impulse control. Brain. 2019 Mar 1;142(3):733-43.

Giehl K, Tahmasian M, Eickhoff SB, van Eimeren T. Imaging executive functions in Parkinson’s disease: An activation likelihood estimation meta-analysis. Parkinsonism & related disorders. 2019 Feb 20.

Baumann A, Nebel A, Granert O, Giehl K, Wolff S, Schmidt W, Baasch C, Schmidt G, Witt K, Deuschl G, Hartwigsen G. Neural Correlates of Hypokinetic Dysarthria and Mechanisms of Effective Voice Treatment in Parkinson Disease. Neurorehabilitation and neural repair. 2018 Dec;32(12):1055-66.

Chong TT, Apps MA, Giehl K, Hall S, Clifton CH, Husain M. Computational modelling reveals distinct patterns of cognitive and physical motivation in elite athletes. Scientific reports. 2018 Aug 8;8(1):11888.

Tahmasian M, Eickhoff SB, Giehl K, Schwartz F, Herz DM, Drzezga A, van Eimeren T, Laird AR, Fox PT, Khazaie H, Zarei M. Resting-state functional reorganization in Parkinson’s disease: an activation likelihood estimation meta-analysis. Cortex. 2017 Jul 1;92:119-38.

Zokaei N, Giehl K, Sillence A, Neville MJ, Karpe F, Nobre AC, Husain M. Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife. cortex. 2017 Mar 1;88:98-105.

Chong TT, Apps M, Giehl K, Sillence A, Grima LL, Husain M. Neurocomputational mechanisms underlying subjective valuation of effort costs. PLoS biology. 2017 Feb 24;15(2):e1002598.

Hammes J, Bischof GN, Giehl K, Faber J, Drzezga A, Klockgether T, van Eimeren T. Elevated in vivo [18F]‐AV‐1451 uptake in a patient with progressive supranuclear palsy. Movement Disorders. 2017 Jan;32(1):170-1.

Rolinski M, Zokaei N, Baig F, Giehl K, Quinnell T, Zaiwalla Z, Mackay CE, Husain M, Hu MT. Visual short-term memory deficits in REM sleep behaviour disorder mirror those in Parkinson’s disease. Brain. 2015 Nov 18;139(1):47-53.

Curriculum Vitae  (download CV as pdf)


Kathrin Giehl, PhD

E-mail: webmaster@mmni.de

Gérard Bischof receives Travel Grant

Dr. Gérard N. Bischof receives a travel grant to present his work on the relationship between CSF markers of p-tau and t-tau to in vivo tau deposition as measured by PET in typical and atypical Alzheimer’s disease at the annual meeting of the Society for Nuclear Medicine and Molecular Imaging (SNMMI) in Denver, USA.

Read the abstract here.

1st Cologne Neuroscience Day

The MMNI group is excited to participate in the very first Cologne Neuroscience Day (CNS) as a platform for young neuroscientists in Cologne to present their work. Talks will be given by Dr. Gérard N. Bischof and Dr. Jochen Hammes.

Read the full program here.