Merle Hönig’s research interest is focused on the investigation of resilience mechanisms in neurodegenerative diseases. As part of her work, she elucidates the role of lifetime factors such as education, occupation, nutrition and physical activity in regard to the occurrence and extent of neuropathology and changes in network function in Alzheimer’s and Parkinson’s disease. In addition, she is interested in genetic and epigenetic changes and how these factors are, in turn, associated with resilience mechanisms.
Hönig MC, Bischof GN, Hammes J, Faber J, Fliessbach K, van Eimeren T, et al. Tau pathology and cognitive reserve in Alzheimer’s disease. Neurobiol Aging. 2017 Sep;57:1–7.
Hönig MC, Bischof GN, Seemiller J, Hammes J, Kukolja J, Onur Ö, Jessen F, Fliessbach K, Neumaier B, Fink GR, van Eimeren T, Drzezga A. Networks of tau distribution in Alzheimer’s disease. Brain, 2018
Hönig MC, Bischof GN, Özgür OA, Kukolja J, Jessen F, Fliessbach K, Neumaier B, Fink GR, Kalbe E, Drzezga A, van Eimeren T: Level of education mitigates the impact of tau pathology on neuronal function. Eur J Nucl Med Mol Imaging.2019 Aug;46(9):1787-1795