2024
Oltra, Javier; Segura, Barbara; Strafella, Antonio P.; van Eimeren, Thilo; Ibarretxe-Bilbao, Naroa; Diez-Cirarda, Maria; Eggers, Carsten; Lucas-Jiménez, Olaia; Monté-Rubio, Gemma C.; Ojeda, Natalia; Peña, Javier; Ruppert, Marina C.; Sala-Llonch, Roser; Theis, Hendrik; Uribe, Carme; Junque, Carme
A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease Journal Article
In: npj Parkinsons Dis., vol. 10, no. 1, 2024, ISSN: 2373-8057.
Abstract | Links | BibTeX | Tags: Cortical thickness, Parkinson, Sex differences, Structural MRI
@article{Oltra2024,
title = {A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease},
author = {Javier Oltra and Barbara Segura and Antonio P. Strafella and Thilo van Eimeren and Naroa Ibarretxe-Bilbao and Maria Diez-Cirarda and Carsten Eggers and Olaia Lucas-Jiménez and Gemma C. Monté-Rubio and Natalia Ojeda and Javier Peña and Marina C. Ruppert and Roser Sala-Llonch and Hendrik Theis and Carme Uribe and Carme Junque},
doi = {10.1038/s41531-024-00686-2},
issn = {2373-8057},
year = {2024},
date = {2024-12-00},
urldate = {2024-12-00},
journal = {npj Parkinsons Dis.},
volume = {10},
number = {1},
publisher = {Springer Science and Business Media LLC},
abstract = {<jats:title>Abstract</jats:title><jats:p>Clinical, cognitive, and atrophy characteristics depending on sex have been previously reported in Parkinson’s disease (PD). However, though sex differences in cortical gray matter measures in early drug naïve patients have been described, little is known about differences in cortical thickness (CTh) as the disease advances. Our multi-site sample comprised 211 non-demented PD patients (64.45% males; mean age 65.58 ± 8.44 years old; mean disease duration 6.42 ± 5.11 years) and 86 healthy controls (50% males; mean age 65.49 ± 9.33 years old) with available T1-weighted 3 T MRI data from four international research centers. Sex differences in regional mean CTh estimations were analyzed using generalized linear models. The relation of CTh in regions showing sex differences with age, disease duration, and age of onset was examined through multiple linear regression. PD males showed thinner cortex than PD females in six frontal (bilateral caudal middle frontal, bilateral superior frontal, left precentral and right pars orbitalis), three parietal (bilateral inferior parietal and left supramarginal), and one limbic region (right posterior cingulate). In PD males, lower CTh values in nine out of ten regions were associated with longer disease duration and older age, whereas in PD females, lower CTh was associated with older age but with longer disease duration only in one region. Overall, male patients show a more widespread pattern of reduced CTh compared with female patients. Disease duration seems more relevant to explain reduced CTh in male patients, suggesting worse prognostic over time. Further studies should explore sex-specific cortical atrophy trajectories using large longitudinal multi-site data.</jats:p>},
keywords = {Cortical thickness, Parkinson, Sex differences, Structural MRI},
pubstate = {published},
tppubtype = {article}
}
<jats:title>Abstract</jats:title><jats:p>Clinical, cognitive, and atrophy characteristics depending on sex have been previously reported in Parkinson’s disease (PD). However, though sex differences in cortical gray matter measures in early drug naïve patients have been described, little is known about differences in cortical thickness (CTh) as the disease advances. Our multi-site sample comprised 211 non-demented PD patients (64.45% males; mean age 65.58 ± 8.44 years old; mean disease duration 6.42 ± 5.11 years) and 86 healthy controls (50% males; mean age 65.49 ± 9.33 years old) with available T1-weighted 3 T MRI data from four international research centers. Sex differences in regional mean CTh estimations were analyzed using generalized linear models. The relation of CTh in regions showing sex differences with age, disease duration, and age of onset was examined through multiple linear regression. PD males showed thinner cortex than PD females in six frontal (bilateral caudal middle frontal, bilateral superior frontal, left precentral and right pars orbitalis), three parietal (bilateral inferior parietal and left supramarginal), and one limbic region (right posterior cingulate). In PD males, lower CTh values in nine out of ten regions were associated with longer disease duration and older age, whereas in PD females, lower CTh was associated with older age but with longer disease duration only in one region. Overall, male patients show a more widespread pattern of reduced CTh compared with female patients. Disease duration seems more relevant to explain reduced CTh in male patients, suggesting worse prognostic over time. Further studies should explore sex-specific cortical atrophy trajectories using large longitudinal multi-site data.</jats:p>